CVE-2026-31968
CWE-121Published: March 18, 2026· Updated: Mar 19, 2026
Official Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. For the `VARINT` and `CONST` encodings, incomplete validation of the context in which the encodings were used could result in up to eight bytes being written beyond the end of a heap allocation, or up to eight bytes being written to the location of a one byte variable on the stack, possibly causing the values to adjacent variables to change unexpectedly. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Technical Analysis
CVE-2026-31968 can be exploited remotely over the network without requiring physical or adjacent access, significantly expanding the attack surface for threat actors.
Exploitation does not require any privileges, though user interaction (Required) is needed, which slightly reduces the risk of mass automated attacks.
A successful exploit results in full integrity compromise (data manipulation), availability disruption (denial of service), with a CVSS base score of 8.1.
CVSS v3.1 Vector Breakdown
Affected Vendors & Products
Exploit & PoC Resources
Official Patches & Advisories
All References (2)
Quick Facts
Related CVEs (CWE-121)
Recommended Actions
- →Apply vendor patches immediately
- →Monitor CVE-2026-31968 in threat intel feeds
- →Review IDS/IPS signatures for exploitation attempts