HOMEVULNERABILITIESCVE-2026-31964
HIGH

CVE-2026-31964

CWE-476Published: March 18, 2026· Updated: Mar 19, 2026

7.5
CVSS v3.1
EPSS:0.04%probability of exploitation in 30 daysPercentile:12.7th

Official Description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

NVD Source

Technical Analysis

CVE-2026-31964 can be exploited remotely over the network without requiring physical or adjacent access, significantly expanding the attack surface for threat actors.

The vulnerability requires no privileges and no user interaction, making it a prime target for automated exploitation campaigns and worm-like propagation.

A successful exploit results in availability disruption (denial of service), with a CVSS base score of 7.5.

CVSS v3.1 Vector Breakdown

Exploitability
Attack VectorNetwork
Attack ComplexityLow
Privileges Req.None
User InteractionNone
ScopeUnchanged
Impact
ConfidentialityNone
IntegrityNone
AvailabilityHigh
CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:N/I:N/A:H

Affected Vendors & Products

htslib1 product
htslib
Source: NVD CPE · 2 total CPE entries

Exploit & PoC Resources

NO KNOWN EXPLOITNo public exploit confirmed at this time
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Official Patches & Advisories

All References (2)

Quick Facts

CVE IDCVE-2026-31964
CVSS Score7.5 / 10
SeverityHIGH
WeaknessCWE-476
CISA KEVNo
EPSS (30d)0.04%
Affected1 vendor
PublishedMar 18, 2026

Related CVEs (CWE-476)

Recommended Actions

  • Apply vendor patches immediately
  • Monitor CVE-2026-31964 in threat intel feeds
  • Review IDS/IPS signatures for exploitation attempts
Data sourced from NVD (NIST), CISA KEV, and EPSS (FIRST). Analysis generated by CTIWATCH.COM. CVE data is provided under the NVD usage policy.