CVE-2026-31964
CWE-476Published: March 18, 2026· Updated: Mar 19, 2026
Official Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Technical Analysis
CVE-2026-31964 can be exploited remotely over the network without requiring physical or adjacent access, significantly expanding the attack surface for threat actors.
The vulnerability requires no privileges and no user interaction, making it a prime target for automated exploitation campaigns and worm-like propagation.
A successful exploit results in availability disruption (denial of service), with a CVSS base score of 7.5.
CVSS v3.1 Vector Breakdown
Affected Vendors & Products
Exploit & PoC Resources
Official Patches & Advisories
All References (2)
Quick Facts
Related CVEs (CWE-476)
Recommended Actions
- →Apply vendor patches immediately
- →Monitor CVE-2026-31964 in threat intel feeds
- →Review IDS/IPS signatures for exploitation attempts